Check Closely (2)pentobarbital will minimize the level or influence of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Strong CYP3A4 inducers may possibly minimize suvorexant efficacy; if improved suvorexant dose demanded, never exceed 20 mg/daypentobarbital improves effects of ifosfamide by affectin