Check Closely (2)pentobarbital will minimize the level or influence of suvorexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. Strong CYP3A4 inducers may possibly minimize suvorexant efficacy; if improved suvorexant dose demanded, never exceed 20 mg/day
pentobarbital improves effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Warning/Observe. Coadministration of ifosfamide with CYP2B6 inducers could raise metabolism of ifosfamide to its metabolite. Observe for improved effects/toxicities if merged with CYP2B6 inducers.
With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs.
pentobarbital will decrease the extent or effect of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with strong CYP3A4 inducers can result in lowered serum concentrations and loss of antimalarial efficacy
Estradiol valerate/dienogest shouldn't be applied for a minimum of 28 days immediately after discontinuation with the inducer on account of chance of lessened contraceptive efficacy.
pentobarbital will decrease the level or outcome of tipranavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will decrease the extent or impact of estropipate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will decrease the extent or result of dutasteride by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
pentobarbital will decrease the level or impact of ritonavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.
pentobarbital will sodium pentobarbital euthanasia decrease the extent or effect of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Coadministration of siponimod with a drug that causes average CYP2C9 in addition a moderate or solid CYP3A4 inducer just isn't recommended.
Observe Intently (1)pentobarbital will decrease the level or impact of gefitinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the level or effect of rabeprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknown.
With therapeutic doses of TCAs, barbiturates maximize metabolism and reduce blood concentrations of TCAs.
pentobarbital will reduce the level or influence of eltrombopag by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Monitor.